Cooler Master Cosmos S Tower Case

Interior of the CM Cosmos S (cont):

The 4-in-3 module is removable, and actually you have to pull it out to install the hard drives. The motherboard tray is not removable, but there is plenty of room to work. Also the tray is offset slightly from the drive bays, allowing for three huge holes in the middle of the case. The holes allow for a convenient place to tuck extra wires and cords out of the way.

As mentioned before, the power supply is mounted at the bottom of the case (and also should be mounted fan side down). The bracket has foam padding on it to reduce noise vibration, and a removable filter is provided. The only downside to the filter is if a fan is mounted in the space in front of it (I don't see many people doing that, but you never know), then that fan will have to be removed whenever one wants to remove the PSU filter.

Finally one quick picture of the case with a regular motherboard and power supply mounted inside. There is plenty of room all around the motherboard to work and route cables. If this case isn't big enough for you then I don't know what would be.